Endocrine Abstracts

Introduction: Diabetes mellitus (DM) has been associated with abnormalities of cardiac function and left ventricular hypertrophy. Diabetic individuals, particularly women, had higher heart rates, greater left ventricular wall thicknesses, greater cardiac mass than unaffected subjects. We aimed to investigate association between waist circumference–body mass index (BMI) and left ventricle mass (LVM)-left ventricle mass index (LVMI), left ventricle myocardial perfusion inde...

Endothelial dysfunction is assessed noninvasively by measuring flow-mediated dilation (FMD). However, FMD is strongly dependent on arterial size, which contributes to a wide range of FMD values. It was previously shown that FMD is greater in small arteries, because the shear stimulus during postocclusion hyperemia is greater in small arteries. We aimed to investigate the predictive value of brachial arterial size on FMD in 44–61 years old Turkish women while adjusting for...

Background: Isolated growth hormone deficiency (IGHD) is a condition associated with the growth failure of children due to deficient growth hormone (GH) production and action. IGHD occurs in 1/4000 to 1/10 000 births and the most of cases are sporadic and idiopathic. Between 5 and 30% show familial pattern, suggesting a genetic etiology of disease. Mutations on GH-1 gene lead to growth failure and cause IGHD disease.Objective: Purpose of our research was...

Background: Diabetes Mellitus (DM) is a disease that increasing in prevalence rapidly in our country and in the world with the increase of sedentary life and unhealthy nutrition. The risks of surgery applied in diabetic patients differ according to other patients.Aim: We aimed to investigate the relationship between the preoperative HbA1c levels and the complications and mortality rates in the postoperative period in patients with diabetes diagnosis and ...

Type III PAS is defined as autoimmune thyroiditis occurs with another organ-specific autoimmune disease. Further PAS IIIA is subclassified as autoimmune thyroiditis with immune-mediated diabetes mellitus. Circulating organ-specific autoantibodies can be detected in these patients. We report a patient with Hashimoto Thyroiditis since five years on levothyroxine treatment with normal TSH levels and new onset insulin dependent Type I DM for 3 months. The patient was admitted Recu...

Aim: FGF-21, is a member of the FGF family that is involved in biological processes such as embryonic development, cellular growth, morphogenesis, tissue repair, tumor growth and invasion, with mitogenic and cellular vital activity activity in the cytogenetic localization of 19q13.33. Breast cancer is the fatal disease most commonly seen in women and increasing in frequency and the relationship between hormones secreted from adipose tissue and some cancers has been shown in re...

Introduction: Langerhans cell histiocytosis (LCH) is a multisystem neoplastic disease with primarily bone and skin involvement. Although its pathogenesis is still not fully understood, LCH lesions contain clonal CD 207+ dendritic cells with the frequently identified BRAF V600E mutation and an inflammatory component. Although isolated central nervous system involvement is extremely rare, a common site of involvement is the hypothalamic-pituitary axis.Case...

Introduction: Insulinoma is the most common functional pancreatic neuroendocrine tumor (PanNET), accounting for more than 50% of all cases. Diagnosis of insulinomas may be challenging. In this study, we aim to discuss the clinicopathological features and long-term follow-up results of insulinoma cases followed up in our clinic.Material and Methods: It is a descriptive and retrospective study of 13 insulinoma cases diagnosed over 10 years. All data of the...

Introduction: Thyroid papillary cancer is a solid organ malignancy that can be cured mostly by surgical and radioactive iodine(RAI) therapy. Metastatic disease state and radioactive iodine resistance have led to new treatment searches. In recent years, sorafenib, a tyrosine kinase inhibitor, has been used as a first-line treatment in thyroid papillary cancers that cannot be cured by surgery or radioactive iodine treatment. In addition, the use of thermal ablation and transarte...

Introduction: Ectopic parathyroid adenomas are detected 16% of patients operated for primary hyperparathyroidism and 22% of them may be located in the anterosuperior mediastinal region. Herein we present a rare case of primary hyperparathyroidism with severe long-term elevated parathormone (PTH) levels due to ectopic parathyroid adenoma in mediastinal region that was successfully treated by using video-assisted thoracic surgery (VATS).Case report: A 38-y...